Plekhg3 Gene Summary [Mouse]
Predicted to enable actin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including alimentary system; choroid plexus; early embryo; respiratory system; and sensory organ. Orthologous to human PLEKHG3 (pleckstrin homology and RhoGEF domain containing G3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhg3 |
| Official Name | pleckstrin homology domain containing, family G (with RhoGef domain) member 3 [Source:MGI Symbol;Acc:MGI:2388284] |
| Ensembl ID | ENSMUSG00000052609 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family G (with RhoGef domain) member 3 |
| Synonyms | ARHGEF43, KIAA0599, pleckstrin homology and RhoGEF domain containing G3, pleckstrin homology domain containing, family G (with RhoGef domain) member 3, RGD1308089 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- actin binding
- guanyl-nucleotide exchange factor
- PH domain
- Pleckstrin homology-like domain
- RhoGEF domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- regulation of cell migration
- regulation of establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding