Bud31 Gene Summary [Mouse]
Predicted to enable nuclear receptor binding activity and transcription coactivator activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of androgen receptor activity. Predicted to be located in chromatin and nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome. Is expressed in central nervous system and genitourinary system. Orthologous to human BUD31 (BUD31 homolog). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bud31 |
| Official Name | BUD31 homolog [Source:MGI Symbol;Acc:MGI:2141291] |
| Ensembl ID | ENSMUSG00000038722 |
| Bio databases IDs | |
| Aliases | BUD31 homolog |
| Synonyms | BUD31 homolog, Cwc14, EDG-2, fSAP17, G10, LPA1, YCR063W |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bud31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- protein binding
- G10 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- non-insulin-dependent diabetes mellitus
- metastasis
- castration refractory prostate cancer
role in cell
- expression in
- phosphorylation in
- cell viability
- apoptosis
- survival
- migration
- invasion by
- splicing by
- intron retention in
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- catalytic step 2 spliceosome
- centrosome
- spliceosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bud31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- positive regulation of androgen receptor activity
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- U2-type catalytic step 2 spliceosome
- spliceosomal complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity