Clec12a Gene Summary [Mouse]
Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in several processes, including negative regulation of dendritic cell differentiation; negative regulation of leukocyte activation; and positive regulation of type I interferon production. Is active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec12a |
| Official Name | C-type lectin domain family 12, member a [Source:MGI Symbol;Acc:MGI:3040968] |
| Ensembl ID | ENSMUSG00000053063 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 12, member a |
| Synonyms | CD371, CLL-1, C-type lectin domain family 12 member A, C-type lectin domain family 12, member A, D230024O04, DCAL-2, hKLRL1, KLRL1, LOC683859, MICL, mKLRL1, mMICL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protein phosphatase binding
- Lectin C-type domain
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- insulin-dependent diabetes mellitus
- infection by bacteria
role in cell
- phosphorylation in
- expression in
- activation
- function
- differentiation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- tertiary granule membrane
- specific granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec12a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- carbohydrate binding
- receptor regulator activity