Fank1 Gene Summary [Mouse]
Predicted to be involved in regulation of DNA-templated transcription and regulation of apoptotic process. Located in ciliary basal body. Is active in ciliary base. Is expressed in lung. Orthologous to human FANK1 (fibronectin type III and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fank1 |
| Official Name | fibronectin type 3 and ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:1914180] |
| Ensembl ID | ENSMUSG00000053111 |
| Bio databases IDs | |
| Aliases | fibronectin type 3 and ankyrin repeat domains 1 |
| Synonyms | 1700007B22RIK, FANK1S, fibronectin type 3 and ankyrin repeat domains 1, fibronectin type III and ankyrin repeat domains 1, HSD13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fank1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- FN3
- Ankyrin repeats (3 copies)
- protein binding
- Fibronectin type 3 domain
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cilia
- basal bodies
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fank1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- regulation of apoptotic process
- positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium basal body
- cilium
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding