A4gnt Gene Summary [Mouse]
This gene encodes a protein from the glycosyltransferase 32 family. The encoded enzyme catalyzes the transfer of N-acetylglucosamine to alpha-1,4-linked beta-galactose residues. This enzyme is required for type III mucin synthesis and it is largely associated with the Golgi apparatus membrane. The encoded protein appears to be expressed in adenocarcinoma cells of pancreatic, biliary tract and gastric cancers.[provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | A4gnt |
| Official Name | alpha-1,4-N-acetylglucosaminyltransferase [Source:MGI Symbol;Acc:MGI:2143261] |
| Ensembl ID | ENSMUSG00000037953 |
| Bio databases IDs | |
| Aliases | alpha-1,4-N-acetylglucosaminyltransferase |
| Synonyms | alpha-1,4-N-acetylglucosaminyltransferase, alpha4GnT, Gm798, RGD1310265, α-1,4-N-acetylglucosaminyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse A4gnt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase sugar-binding region containing DXD motif
- Alpha 1,4-glycosyltransferase conserved region
- acetylglucosaminyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- gastrointestinal neoplasia
- gastric epithelial cancer
- gastric cancer
- gastroesophageal cancer
- abdominal cancer
- gastrointestinal tract cancer
regulates
- mucin III
- carbohydrate
- O-glycan
- glycoprotein
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse A4gnt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- epithelial cell proliferation
- protein O-linked glycosylation
- glycoprotein biosynthetic process
- negative regulation of epithelial cell proliferation
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- acetylglucosaminyltransferase activity