Daw1 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within several processes, including cerebrospinal fluid circulation; determination of left/right symmetry; and outer dynein arm assembly. Predicted to be located in ciliary basal body. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in node. Used to study Kartagener syndrome; primary ciliary dyskinesia; and visceral heterotaxy. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DAW1 (dynein assembly factor with WD repeats 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Daw1 |
| Official Name | dynein assembly factor with WDR repeat domains 1 [Source:MGI Symbol;Acc:MGI:1923089] |
| Ensembl ID | ENSMUSG00000053161 |
| Bio databases IDs | |
| Aliases | dynein assembly factor with WDR repeat domains 1 |
| Synonyms | 4930563E19Rik, 4933429D11Rik, b2b1116Clo, b2b1584Clo, CILD52, DNAAF18, dynein assembly factor with WD repeats 1, dynein assembly factor with WDR repeat domains 1, ODA16, WDR69 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Daw1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergic rhinitis
- dementia
- primary ciliary dyskinesia type 52 with situs inversus
- primary ciliary dyskinesia
- situs ambiguus
- idiopathic scoliosis
- primary ciliary dyskinesia type 52
- congenital heart disease
regulates
- Axonemal Dynein Outer Arm
role in cell
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cilia
- basal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Daw1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- outer dynein arm assembly
- intraflagellar transport
- protein polyubiquitination
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- motile cilium
- cytoplasm
- cilium basal body
- cilium
- SCF ubiquitin ligase complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding