Suv39h1 Gene Summary [Mouse]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and histone H3K9me2 methyltransferase activity. Involved in circadian rhythm; negative regulation of DNA-templated transcription; and negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including blastocyst hatching; determination of adult lifespan; and regulation of bone mineralization. Located in heterochromatin and nucleus. Part of chromatin silencing complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suv39h1 |
| Official Name | suppressor of variegation 3-9 1 [Source:MGI Symbol;Acc:MGI:1099440] |
| Ensembl ID | ENSMUSG00000039231 |
| Bio databases IDs | |
| Aliases | suppressor of variegation 3-9 1 |
| Synonyms | DXHXS7466e, H3-K9-HMTase 1, KMT1A, MG44, mIS6, RGD1565028, suppressor of variegation 3-9 1, SUV39H, SUV39H1 histone lysine methyltransferase, Suv39h1l1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Suv39h1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- nucleic acid binding
- chromatin binding
- enzyme
- protein binding
- sequence-specific DNA binding
- S-adenosylmethionine-dependent methyltransferase
- histone lysine N-methyltransferase activity (H3-K9 specific)
- Pre-SET motif
- protein methyltransferase
- histone methyltransferase
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- double-stranded DNA binding
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- Chromo (CHRromatin organization MOdifier) domain
- N-terminal to some SET domains
Pathways
Biological processes and signaling networks where the Suv39h1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- Bladder Cancer Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Sirtuin Signaling Pathway
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- tumorigenesis
- KMT2A rearrangement positive acute myeloid leukemia
role in cell
- proliferation
- binding
- expression in
- formation
- production in
- cell viability
- binding in
- growth
- transcription in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- centromeric region
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- chromosomal arms
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Suv39h1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell cycle
- regulation of transcription by glucose
- rRNA processing
- chromatin organization
- response to DNA damage stimulus
- circadian rhythm
- cellular response to glucose starvation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- chromatin silencing at rDNA
- energy homeostasis
- cell differentiation
- cellular response to hypoxia
- methylation
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- cytoplasmic vesicle
- rDNA heterochromatin
- chromosome, centromeric region
- nucleolus
- nuclear lamina
- plasma membrane
- chromatin silencing complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- histone methyltransferase activity
- histone methyltransferase activity (H3-K9 specific)
- transcription regulatory region sequence-specific DNA binding
- chromatin binding
- S-adenosylmethionine-dependent methyltransferase activity