Odf2 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Predicted to be involved in cilium organization and regulation of cilium assembly. Located in microtubule organizing center and sperm flagellum. Part of ciliary transition fiber. Is expressed in several structures, including brain; early conceptus; inner ear; liver; and reproductive system. Orthologous to human ODF2 (outer dense fiber of sperm tails 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Odf2 |
| Official Name | outer dense fiber of sperm tails 2 [Source:MGI Symbol;Acc:MGI:1098824] |
| Ensembl ID | ENSMUSG00000026790 |
| Bio databases IDs | |
| Aliases | outer dense fiber of sperm tails 2 |
| Synonyms | AI848335, CT134, MMTEST29, ODF84, outer dense fiber of sperm tails 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Odf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RecF/RecN/SMC N terminal domain
- Tropomyosin
- RIM-binding protein of the cytomatrix active zone
- chromosome segregation protein SMC, primarily archaeal type
- structural constituent of cytoskeleton
- enzyme binding
- helix-rich Mycoplasma protein
- Intermediate filament protein
- protein binding
- structural molecule
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Septation ring formation regulator, EzrA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- incoordination
- cough
role in cell
- formation
- assembly
- formation in
- development
- ciliogenesis
- ciliogenesis in
- segregation
- organization
- segregation in
- alignment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mother centriole
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- grandmother centriole
- basal foot
- anchoring fibrils
- ciliary transition fiber
- cilia
- cellular tail
- basal bodies
- centrosome
- centriole
- microtubule organizing centers
- cytosol
- spindle pole
- sperm midpiece
- sperm tail
- outer dense fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Odf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- centriole-centriole cohesion
- protein localization
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- sperm midpiece
- centriole
- intracellular membrane-bounded organelle
- spindle pole
- cytosol
- sperm principal piece
- sperm flagellum
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity