Btn2a2 Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Involved in negative regulation of activated T cell proliferation and negative regulation of cytokine production. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of signal transduction; and positive regulation of regulatory T cell differentiation. Located in cell surface. Orthologous to several human genes including BTN2A2 (butyrophilin subfamily 2 member A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btn2a2 |
| Official Name | butyrophilin, subfamily 2, member A2 [Source:MGI Symbol;Acc:MGI:3606486] |
| Ensembl ID | ENSMUSG00000053216 |
| Bio databases IDs | |
| Aliases | butyrophilin, subfamily 2, member A2 |
| Synonyms | BT2.2, BTF2, BTN2, butyrophilin subfamily 2 member A2, butyrophilin, subfamily 2, member A2, D030063K05 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Btn2a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- SPRY domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- associated with SPRY domains
- SPRY-associated domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- experimental autoimmune encephalomyelitis
- headache
- chronic pain
- post-traumatic stress disorder
role in cell
- cell cycle progression
- proliferation
- expression in
- activation in
- differentiation
- number
- quantity
- function
- metabolism by
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Btn2a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of activated T cell proliferation
- positive regulation of regulatory T cell differentiation
- ERK1 and ERK2 cascade
- protein kinase B signaling cascade
- negative regulation of T cell receptor signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- G1/S transition of mitotic cell cycle
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of cytokine production
- negative regulation of cytokine production
- T cell receptor signaling pathway
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding