BTN2A2 Gene Summary [Human]
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | BTN2A2 |
| Official Name | butyrophilin subfamily 2 member A2 [Source:HGNC Symbol;Acc:HGNC:1137] |
| Ensembl ID | ENSG00000124508 |
| Bio databases IDs | |
| Aliases | butyrophilin subfamily 2 member A2 |
| Synonyms | BT2.2, BTF2, BTN2, butyrophilin subfamily 2 member A2, butyrophilin, subfamily 2, member A2, D030063K05 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTN2A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- SPRY domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- associated with SPRY domains
- SPRY-associated domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- experimental autoimmune encephalomyelitis
- headache
- chronic pain
- post-traumatic stress disorder
role in cell
- cell cycle progression
- proliferation
- expression in
- activation in
- differentiation
- number
- quantity
- function
- metabolism by
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BTN2A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of activated T cell proliferation
- positive regulation of regulatory T cell differentiation
- ERK1 and ERK2 cascade
- protein kinase B signaling cascade
- negative regulation of T cell receptor signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- G1/S transition of mitotic cell cycle
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of cytokine production
- negative regulation of cytokine production
- T cell receptor signaling pathway
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding