Dennd4a Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rab protein signal transduction. Predicted to be active in cytoplasmic vesicle. Is expressed in liver left lobe and liver right lobe. Orthologous to human DENND4A (DENN domain containing 4A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dennd4a |
| Official Name | DENN/MADD domain containing 4A [Source:MGI Symbol;Acc:MGI:2142979] |
| Ensembl ID | ENSMUSG00000053641 |
| Bio databases IDs | |
| Aliases | DENN/MADD domain containing 4A |
| Synonyms | AI115600, DENN domain containing 4A, F730015K02Rik, IRLB, MBP-1, MYCPBP, RGD1562639 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dennd4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RXXs motif
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- PPR repeat family
- dDENN domain
- protein binding
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Hutchinson-Gilford progeria syndrome
- Alzheimer disease
- idiopathic scoliosis
role in cell
- cell viability
- number
- necroptosis
- progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dennd4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rab protein signal transduction
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- guanyl-nucleotide exchange factor activity