Tgm5 Gene Summary [Mouse]
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in peeling skin syndrome 2. Orthologous to human TGM5 (transglutaminase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgm5 |
| Official Name | transglutaminase 5 [Source:MGI Symbol;Acc:MGI:1921426] |
| Ensembl ID | ENSMUSG00000053675 |
| Bio databases IDs | |
| Aliases | transglutaminase 5 |
| Synonyms | 2310007C07Rik, LOC120093166, LOC688030, LOC688031, PSS2, TGASE5, TGASEX, TGM6, Tgm7l1, TGMX, TGX, TG(X), transglutaminase 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- Transglutaminase/protease-like homologues
- protein-glutamine gamma-glutamyltransferase
- enzyme
- protein binding
- Transglutaminase family, C-terminal ig like domain
- Transglutaminase family
Pathways
Biological processes and signaling networks where the Tgm5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- perinuclear region
- Plasma Membrane
- intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgm5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- epidermis development
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein-glutamine gamma-glutamyltransferase activity
- protein binding
- metal ion binding