TGM5
TGM5 Gene Summary
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | TGM5 |
| Official Name | transglutaminase 5 [Source:HGNC Symbol;Acc:HGNC:11781] |
| Ensembl ID | ENSG00000104055 |
| Bio databases IDs | |
| Aliases | transglutaminase 5, protein-glutamine gamma-glutamyltransferase 5 |
| Synonyms | 2310007C07Rik,LOC120093166,LOC688030,LOC688031,PSS2,TGASE5,TGASEX,TGM6,Tgm7l1,TGMX,TGX,TG(X),transglutaminase 5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- Transglutaminase/protease-like homologues
- protein-glutamine gamma-glutamyltransferase
- enzyme
- protein binding
- Transglutaminase family, C-terminal ig like domain
- Transglutaminase family
Pathways
Biological processes and signaling networks where the TGM5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- INTS14
- CCDC51
- RFTN1
- GRB7
- ESR2
- PRPF40A
- RBM41
- ZNHIT6
- LAMP2
- NHLRC2
disease
- acral peeling skin syndrome
- peeling skin syndrome type 1
- hereditary disorder
- spinocerebellar ataxia type 1
regulated by
- Propionibacterium acnes JCM 6425
- Propionibacterium acnes JCM 6473
regulates
- ATXN1
role in cell
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- perinuclear region
- Plasma Membrane
- intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TGM5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein modification process
- epidermis development
- peptide cross-linking
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein-glutamine gamma-glutamyltransferase activity
- protein binding
- metal ion binding