Rftn1 Gene Summary [Mouse]
Predicted to enable double-stranded RNA binding activity. Involved in several processes, including T cell antigen processing and presentation; T cell receptor signaling pathway; and positive regulation of interleukin-17 production. Predicted to be located in endosome; membrane raft; and plasma membrane. Predicted to be part of protein-containing complex. Is expressed in brain and dorsal grey horn. Orthologous to human RFTN1 (raftlin, lipid raft linker 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rftn1 |
| Official Name | raftlin lipid raft linker 1 [Source:MGI Symbol;Acc:MGI:1923688] |
| Ensembl ID | ENSMUSG00000039316 |
| Bio databases IDs | |
| Aliases | raftlin lipid raft linker 1 |
| Synonyms | 2310015N21Rik, MIG2, PIB10, PIG9, RAFTLIN, raftlin lipid raft linker 1, raftlin, lipid raft linker 1, RGD1310777, RGD1563347 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rftn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded RNA binding
- Raftlin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- obesity
- mantle cell lymphoma
- polyglandular autoimmune syndrome type 1
- experimental autoimmune encephalomyelitis
- thoracic aortic aneurysm
role in cell
- production in
- differentiation
- activation in
- number
- internalization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- detergent resistant lipid raft fraction
- Cytoplasm
- endosomes
- membrane rafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rftn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell antigen processing and presentation
- membrane raft assembly
- positive regulation of growth rate
- response to exogenous dsRNA
- toll-like receptor 3 signaling pathway
- positive regulation of interleukin-17 production
- protein transport into membrane raft
- T cell receptor signaling pathway
- dsRNA transport
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome
- extracellular vesicular exosome
- endosome
- cytoplasm
- membrane raft
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- double-stranded RNA binding