Ech1 Gene Summary [Mouse]
Predicted to enable delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; liver; and nervous system. Orthologous to human ECH1 (enoyl-CoA hydratase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ech1 |
| Official Name | enoyl coenzyme A hydratase 1, peroxisomal [Source:MGI Symbol;Acc:MGI:1858208] |
| Ensembl ID | ENSMUSG00000053898 |
| Bio databases IDs | |
| Aliases | enoyl coenzyme A hydratase 1, peroxisomal |
| Synonyms | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial, Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, peroxisomal, enoyl-CoA hydratase 1, enoyl coenzyme A hydratase 1, peroxisomal, HIP11, HPXEL, Mitochondrial dienoyl-coa isomerase, Perox enolhydratase, Peroxisomal enoyl hydratase-like, Pxel, δ(3,5)-δ(2,4)-dienoyl-CoA isomerase, mitochondrial, δ(3,5)-δ(2,4)-dienoyl-CoA isomerase, peroxisomal |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ech1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- naphthoate synthase (dihydroxynaphthoic acid synthetase)
- phenylacetate degradation probable enoyl-CoA hydratase paaB
- crotonase-like
- enzyme
- protein binding
- Enoyl-CoA hydratase/isomerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- peroxisomal matrix
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial matrix
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ech1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
Cellular Component
Where in the cell the gene product is active
- peroxisome
- extracellular vesicular exosome
- mitochondrial matrix
- membrane
- mitochondrion
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- delta3,5-delta2,4-dienoyl-CoA isomerase activity
- protein binding