Parp4 Gene Summary [Mouse]
Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Predicted to be involved in inflammatory response and protein modification process. Predicted to be located in cytosol; nucleoplasm; and spindle microtubule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in cerebral cortex. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Parp4 |
| Official Name | poly (ADP-ribose) polymerase family, member 4 [Source:MGI Symbol;Acc:MGI:2685589] |
| Ensembl ID | ENSMUSG00000054509 |
| Bio databases IDs | |
| Aliases | poly (ADP-ribose) polymerase family, member 4 |
| Synonyms | ADP-RIBOSYLTRANSFERASE L1, ADPRTL1, ARTD4, C030027K23Rik, E230037B21, E230037B21Rik, Gm743, p193, PARPL, PH5P, poly (ADP-ribose) polymerase family, member 4, poly(ADP-ribose) polymerase family member 4, VAULT3, VPARP, VWA5C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Parp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- BRCT
- Vault protein inter-alpha-trypsin domain
- von Willebrand factor (vWF) type A domain
- catalytic domain
- NAD ADP-ribosyltransferase
- VPARP MVP interacting domain
- BRCT domain, a BRCA1 C-terminus domain
- Poly(ADP-ribose) polymerase, regulatory domain
- Poly(ADP-ribose) polymerase catalytic domain
- enzyme binding
- enzyme
- von Willebrand factor type A domain
- protein binding
- ADP_ribosyl
- DNA binding
- pentosyltransferase
- vWFA
- BRCA1 C Terminus (BRCT) domain
- breast cancer carboxy-terminal domain
Pathways
Biological processes and signaling networks where the Parp4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribonucleoprotein fractions
- nuclear fraction
- spindle apparatus
- Nucleus
- cytosol
- nucleoplasm
- spindle fibers
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Parp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of telomerase activity
- DNA repair
- protein modification process
- inflammatory response
- response to xenobiotic stimulus
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle microtubule
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- nucleotidyltransferase activity
- protein binding
- NAD+ ADP-ribosyltransferase activity
- enzyme binding