Tep1 Gene Summary [Mouse]
Enables telomerase RNA binding activity. Contributes to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Part of telomerase holoenzyme complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and stomach cancer. Orthologous to human TEP1 (telomerase associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tep1 |
| Official Name | telomerase associated protein 1 [Source:MGI Symbol;Acc:MGI:109573] |
| Ensembl ID | ENSMUSG00000006281 |
| Bio databases IDs | |
| Aliases | telomerase associated protein 1 |
| Synonyms | p240, telomerase associated protein 1, TLP1, TP1, TROVE1, VAULT2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tep1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA ATPase domain
- Domain of unknown function (DUF5920)
- Domain of unknown function (DUF4062)
- WD domain, G-beta repeat
- enzyme binding
- WD40
- enzyme
- p53 binding
- protein binding
- TROVE domain
- NACHT domain
- RNA binding
- TEP1 N-terminal domain
- WD40 repeats
- telomerase
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Tep1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein fractions
- nuclear fraction
- Cytoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tep1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA-dependent DNA replication
- telomere maintenance via recombination
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- cytoplasm
- nuclear matrix
- telomerase holoenzyme complex
Molecular Function
What the gene product does at the molecular level
- telomerase activity
- ATP binding
- p53 binding
- protein binding
- RNA binding
- telomeric RNA binding
- enzyme binding