Gabra5 Gene Summary [Mouse]
Enables GABA-A receptor activity and GABA-gated chloride ion channel activity. Involved in cochlea development; inner ear receptor cell development; and innervation. Acts upstream of or within associative learning and behavioral fear response. Located in cell body and dendrite. Is expressed in several structures, including brain and palatal shelf. Human ortholog(s) of this gene implicated in bipolar disorder; depressive disorder; and developmental and epileptic encephalopathy 79. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabra5 |
| Official Name | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 [Source:MGI Symbol;Acc:MGI:95617] |
| Ensembl ID | ENSMUSG00000055078 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 |
| Synonyms | A230018I05Rik, DEE79, EIEE79, GABAA Alpha 5, Gaba A receptor subunit α 5, Gaba A receptor α-5, GABAA α 5, gamma-aminobutyric acid type A receptor subunit alpha 5, LOC100509612, LOC727729, γ-aminobutyric acid type A receptor subunit alpha5, γ-aminobutyric acid type A receptor subunit α 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabra5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- intracellular loop
- signaling receptor activity
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- intracellular M3-M4 domain
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- receptor binding
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
- loop domain
Pathways
Biological processes and signaling networks where the Gabra5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- pneumonia
- sepsis
- acute renal failure
- postoperative pain
- weight gain
- insomnia
- depressive disorder
- anxiety disorder
- dementia
regulates
- chloride
role in cell
- degeneration
- development
- long-term potentiation
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- somatodendritic region
- cellular membrane
- cytosol
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- nucleoplasm
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabra5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- cochlea development
- signal transduction
- innervation
- inner ear receptor cell development
- synaptic transmission, GABAergic
- associative learning
- gamma-aminobutyric acid signaling pathway
- behavioral fear response
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- chloride channel complex
- dendrite membrane
- cytosol
- neuronal cell body membrane
- synapse
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity
- GABA-A receptor activity
- chloride channel activity
- GABA receptor binding
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity