Fat2 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-substrate adhesion; epithelial cell migration; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; nose; and urinary system. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fat2 |
| Official Name | FAT atypical cadherin 2 [Source:MGI Symbol;Acc:MGI:2685369] |
| Ensembl ID | ENSMUSG00000055333 |
| Bio databases IDs | |
| Aliases | FAT atypical cadherin 2 |
| Synonyms | CDHF8, CDHR9, EMI2, FAT atypical cadherin 2, Fath2, Gm523, HFAT2, MEGF1, mKIAA0811, SCA45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LamG
- Human growth factor-like EGF
- Cadherin repeat-like domain
- laminin G domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- nasopharyngeal cancer
- nasopharyngeal carcinoma
- epithelial cancer
- spinocerebellar ataxia type 45
- mixed sarcomatoid-epithelial nasopharyngeal carcinoma
- mixed neoplasia
- sarcomatoid cancer
- liver cancer
- B-cell non-Hodgkin disease
role in cell
- adhesion
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homophilic cell adhesion
- cell-substrate adhesion
- epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- extracellular vesicular exosome
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding