Rpl7a Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA. Located in cytoplasm; membrane; and ribosome. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in embryo; metanephros; neocortex; spleen; and thymus. Orthologous to human RPL7A (ribosomal protein L7a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl7a |
| Official Name | ribosomal protein L7A [Source:MGI Symbol;Acc:MGI:1353472] |
| Ensembl ID | ENSMUSG00000062647 |
| Bio databases IDs | |
| Aliases | ribosomal protein L7A |
| Synonyms | eL8, L7A, PLA-X, ribosomal protein L7A, SURF3, Surfeit 3, TRUP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- U4/U6.U5 small nuclear ribonucleoprotein SNU13
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl7a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
regulates
- reporter gene
- TP53
- thyroid hormone receptor
- RAR
role in cell
- expression in
- cell death
- G1 phase
- autophagy
- G2/M phase transition
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- nuclear fraction
- cellular membrane
- ribosome
- Nucleus
- cytosol
- nucleoli
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- synapse
- cytosolic large ribosomal subunit
- ribosome
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- cadherin binding