Zzef1 Gene Summary [Mouse]
Enables ubiquitin-like protein ligase activity. Acts upstream of or within several processes, including glutamatergic synaptic transmission; regulation of peptidyl-tyrosine phosphorylation; and visual learning. Located in cell surface; postsynapse; and presynaptic active zone. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zzef1 |
| Official Name | zinc finger, ZZ-type with EF hand domain 1 [Source:MGI Symbol;Acc:MGI:2444286] |
| Ensembl ID | ENSMUSG00000055670 |
| Bio databases IDs | |
| Aliases | zinc finger, ZZ-type with EF hand domain 1 |
| Synonyms | 8430405D05Rik, C130099L13Rik, LOC730889, mKIAA0399, NSPA, zinc finger ZZ-type and EF-hand domain containing 1, zinc finger, ZZ-type with EF hand domain 1, ZZZ4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zzef1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- histone binding
- EF-hand, calcium binding motif
- transcription regulator
- EF-hand domain
- APC10-like
- protein binding activity, bridging
- F5/8 type C domain
- ubiquitin-like-protein ligase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- postsynaptic region
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zzef1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin organization
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- methylated histone residue binding
- calcium ion binding
- histone acetyl-lysine binding