Sema3c Gene Summary [Mouse]
Enables semaphorin receptor binding activity. Involved in several processes, including cardiac endothelial to mesenchymal transition; chordate embryonic development; and circulatory system development. Acts upstream of or within several processes, including blood vessel remodeling; dichotomous subdivision of terminal units involved in salivary gland branching; and neural crest cell migration. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and respiratory system. Orthologous to human SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema3c |
| Official Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [Source:MGI Symbol;Acc:MGI:107557] |
| Ensembl ID | ENSMUSG00000028780 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| Synonyms | 1110036B02Rik, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C, SEMAE, semaphorin 3C, Semaphorin E, SemE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- semaphorin receptor binding
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- pancreatic ductal adenocarcinoma
- hypothyroidism
- Langerhans cell histiocytosis
- chronic obstructive pulmonary disease
- pervasive developmental disorder
- pancreatic epithelial cancer
- ductal pancreatic cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- expression in
- phosphorylation in
- growth
- cell viability
- apoptosis
- proliferation
- migration
- influx
- colony formation by
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- negative chemotaxis
- limb bud formation
- post-embryonic development
- axon guidance
- pulmonary myocardium development
- response to xenobiotic stimulus
- dichotomous subdivision of terminal units involved in salivary gland branching
- outflow tract septum morphogenesis
- cardiac right ventricle morphogenesis
- blood vessel remodeling
- immune response
- neural crest cell migration
- somitogenesis
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding