Ticam2 Gene Summary [Mouse]
Enables phospholipid binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of interleukin-18-mediated signaling pathway; and response to interleukin-12. Acts upstream of or within defense response to virus and regulation of cytokine production. Located in endosome and plasma membrane. Is expressed in testis and ureter. Used to study Coronavirus infectious disease. Orthologous to human TICAM2 (TIR domain containing adaptor molecule 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ticam2 |
| Official Name | toll-like receptor adaptor molecule 2 [Source:MGI Symbol;Acc:MGI:3040056] |
| Ensembl ID | ENSMUSG00000056130 |
| Bio databases IDs | |
| Aliases | toll-like receptor adaptor molecule 2 |
| Synonyms | B430113A10, MyD88-4, TIRAP3, TIR domain containing adaptor molecule 2, TIRP, TOLL-LIKE receptor ADAPTER MOLECULE 2, TRAM, Trif, TRIF-RELATED ADAPTER MOLECULE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ticam2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- interleukin-1 receptor binding
- myristoylation sequence
- BB loop
- protein binding
- TIR domain
- protein heterodimerization
- myristoylation site
Pathways
Biological processes and signaling networks where the Ticam2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by coronavirus
role in cell
- activation in
- binding in
- apoptosis
- expression in
- proliferation
- production in
- phosphorylation in
- cell death
- quantity
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- endosomal membrane
- early endosomes
- late endosomes
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ticam2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- positive regulation of interleukin-18-mediated signaling pathway
- cellular response to lipopolysaccharide
- positive regulation of toll-like receptor 4 signaling pathway
- positive regulation of type I interferon production
- innate immune response
- toll-like receptor 4 signaling pathway
- phagocytosis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- TRAM-dependent toll-like receptor 4 signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- secretory granule membrane
- endosome
- Golgi apparatus
- endosome membrane
- endoplasmic reticulum
- cell projection
- phagocytic cup
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity
- binding, bridging