Tlr3

Enables pattern recognition receptor activity; transmembrane signaling receptor activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of macromolecule biosynthetic process; and response to virus. Acts upstream of or within several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of cytokine production. Is active in plasma membrane. Is expressed in blood; brain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tlr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlr3 gene, providing context for its role in the cell.