St8sia3 Gene Summary [Mouse]
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Involved in ganglioside biosynthetic process and sialylation. Predicted to be located in Golgi membrane. Is expressed in brain; cortical plate; and testis. Orthologous to human ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St8sia3 |
| Official Name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [Source:MGI Symbol;Acc:MGI:106019] |
| Ensembl ID | ENSMUSG00000056812 |
| Bio databases IDs | |
| Aliases | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 |
| Synonyms | Alpha-2,8-sialyltransferase, SIAT8C, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, ST8SiaIII, ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 3, α-2,8-sialyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St8sia3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
- sialyltransferase
- miscellaneous glycosyl group transferase
- enzyme
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St8sia3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein metabolic process
- N-glycan processing
- protein glycosylation
- oligosaccharide metabolic process
- glycosphingolipid biosynthetic process
- ganglioside biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sialic acid binding
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity