Tmem59 Gene Summary [Mouse]
Enables endopeptidase activity. Predicted to be involved in negative regulation of protein localization to plasma membrane and positive regulation of autophagy. Predicted to act upstream of or within with a negative effect on protein glycosylation. Predicted to be located in Golgi cis cisterna; Golgi medial cisterna; and Golgi trans cisterna. Predicted to be active in late endosome and lysosome. Is expressed in several structures, including alveolar sulcus; central nervous system; olfactory epithelium; retina; and skeleton. Orthologous to human TMEM59 (transmembrane protein 59). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem59 |
| Official Name | transmembrane protein 59 [Source:MGI Symbol;Acc:MGI:1929278] |
| Ensembl ID | ENSMUSG00000028618 |
| Bio databases IDs | |
| Aliases | transmembrane protein 59 |
| Synonyms | 1110001M20RIK, 3110046P06RIK, C1orf8, D4Ertd20e, DCF1, HSPC001, MTDCF1, ORF18, PRO195, RGD1310313, Shd11, transmembrane protein 59, UNQ169 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem59 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase
- Brain specific membrane anchored protein
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- pervasive developmental disorder
- lichen planus
- colon cancer
- leiomyomatosis
- augmented response of hdl cholesterol to hormone replacement
role in cell
- function
- generation in
- abnormal morphology
- autophagy by
- shedding in
- retention in
- O-glycosylation in
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lysosome
- late endosomes
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem59 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- autophagy
- protein glycosylation
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- extracellular vesicular exosome
- late endosome
- Golgi membrane
- Golgi trans cisterna
- Golgi cis cisterna
- plasma membrane
- lysosomal membrane
- Golgi medial cisterna
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity