Immp2l Gene Summary [Mouse]
Enables peptidase activity. Acts upstream of or within several processes, including cerebellum vasculature development; ovulation; and protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Immp2l |
| Official Name | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2135611] |
| Ensembl ID | ENSMUSG00000056899 |
| Bio databases IDs | |
| Aliases | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) |
| Synonyms | IMMP2L-IT1, IMP2, IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae), IMP2-LIKE, inner mitochondrial membrane peptidase subunit 2, Tg(HLA-A/H2-D)2Enge |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Immp2l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signal peptidase I, bacterial type
- nickel-type superoxide dismutase maturation protease
- peptidase
- protein binding
- Signal peptidase, peptidase S26
- Peptidase_S24_S26
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- major depression
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- pervasive developmental disorder
role in cell
- expression in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Immp2l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellum vasculature development
- spermatogenesis
- respiratory electron transport chain
- blood circulation
- signal peptide processing
- brain development
- response to DNA damage stimulus
- ovarian follicle development
- protein processing involved in protein targeting to mitochondrion
- superoxide metabolic process
- ovulation
- mitochondrial respiratory chain complex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane peptidase complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- endopeptidase activity
- serine-type endopeptidase activity
- peptidase activity