Prkag1 Gene Summary [Mouse]
Predicted to enable several functions, including adenyl ribonucleotide binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to contribute to AMP-activated protein kinase activity. Involved in import into nucleus. Located in nucleus. Is expressed in several structures, including future brain; heart; liver; and nervous system. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkag1 |
| Official Name | protein kinase, AMP-activated, gamma 1 non-catalytic subunit [Source:MGI Symbol;Acc:MGI:108411] |
| Ensembl ID | ENSMUSG00000067713 |
| Bio databases IDs | |
| Aliases | protein kinase, AMP-activated, gamma 1 non-catalytic subunit |
| Synonyms | AMPKG, Ampk gamma, AMPK gamma1, Ampk γ, Ampk γ 1, Prkaac, Prkga1, protein kinase, AMP-activated, gamma 1 non-catalytic subunit, protein kinase AMP-activated non-catalytic subunit gamma 1, protein kinase AMP-activated non-catalytic subunit γ 1, protein kinase, AMP-activated, γ 1 non-catalytic subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkag1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in cystathionine beta-synthase and other proteins
- cAMP-dependent protein kinase
- protein kinase
- protein kinase binding
- ADP binding
- CBS domain
- ATP binding
- protein kinase regulator
- protein binding
- cAMP-dependent protein kinase regulator
- SNF1A/AMP-activated protein kinase
- kinase
- CBS_pair_SF
- AMP binding
- binding protein
Pathways
Biological processes and signaling networks where the Prkag1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Glucocorticoid Receptor Signaling
- IL-1 Signaling
- IL-12 Signaling and Production in Macrophages
- Leptin Signaling in Obesity
- Melatonin Signaling
- Netrin Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Relaxin Signaling
- Renin-Angiotensin Signaling
- Sonic Hedgehog Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- colorectal adenocarcinoma
- colorectal carcinomagenesis
- microcytosis
- hemolytic anemia
- anisocytosis
- pervasive developmental disorder
- glioblastoma cancer
- macrocytosis
role in cell
- quantity
- number
- function
- cell cycle progression
- abnormal morphology
- glycolysis in
- clearance
- deformability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkag1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to nutrient levels
- positive regulation of protein kinase activity
- signal transduction
- spermatogenesis
- positive regulation of gene expression
- regulation of catalytic activity
- nuclear import
- regulation of glycolysis
- protein phosphorylation
- fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- nucleoplasm
- AMP-activated protein kinase complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- AMP binding
- protein binding
- cAMP-dependent protein kinase activity
- protein kinase activity
- ADP binding
- protein kinase regulator activity
- cAMP-dependent protein kinase regulator activity