Mxd1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleoplasm. Predicted to be part of Mad-Max complex. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; integumental system; and sensory organ. Orthologous to human MXD1 (MAX dimerization protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mxd1 |
| Official Name | MAX dimerization protein 1 [Source:MGI Symbol;Acc:MGI:96908] |
| Ensembl ID | ENSMUSG00000001156 |
| Bio databases IDs | |
| Aliases | MAX dimerization protein 1 |
| Synonyms | BHLHC58, MAD, MAD1, MAX dimerization protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mxd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- Sin3 binding domain
- basic Helix Loop Helix (bHLH) domain superfamily
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- basic helix-loop-helix-leucine zipper domain
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- basic domain
Pathways
Biological processes and signaling networks where the Mxd1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- renal cell cancer
- diabetes mellitus
- atrial fibrillation
- endometriosis
- primary myelofibrosis
- Marfan syndrome
- renal cell carcinoma
- severe acute respiratory syndrome
- neoplastic cell transformation
role in cell
- apoptosis
- expression in
- proliferation
- colony formation
- differentiation
- growth
- quantity
- G1 phase
- migration
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mxd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- Mad-Max complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity