Foxb1 Gene Summary [Mouse]
Enables sequence-specific DNA binding activity. Involved in several processes, including mammary gland development; nervous system development; and visual learning. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; jaw; limb; and paraxial mesenchyme. Orthologous to human FOXB1 (forkhead box B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxb1 |
| Official Name | forkhead box B1 [Source:MGI Symbol;Acc:MGI:1927549] |
| Ensembl ID | ENSMUSG00000059246 |
| Bio databases IDs | |
| Aliases | forkhead box B1 |
| Synonyms | C43, FKH5, forkhead box B1, Foxb1a, Foxb1b, Hfh-e5.1, HFKH-5, Mf3, Twh |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mammary gland lobule development
- epithelial cell differentiation involved in mammary gland alveolus development
- mammillothalamic axonal tract development
- telencephalon cell migration
- anatomical structure morphogenesis
- lactation
- visual learning
- hypothalamus cell migration
- mammillary body development
- inferior colliculus development
- thalamus development
- axon target recognition
- regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
- spinal cord development
- midbrain development
- urogenital system development
- somitogenesis
- cell differentiation
- cell migration in diencephalon
- floor plate development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity