Arid3a Gene Summary [Mouse]
Enables several functions, including chromatin binding activity; identical protein binding activity; and transcription coregulator activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Orthologous to human ARID3A (AT-rich interaction domain 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arid3a |
| Official Name | AT rich interactive domain 3A (BRIGHT-like) [Source:MGI Symbol;Acc:MGI:1328360] |
| Ensembl ID | ENSMUSG00000019564 |
| Bio databases IDs | |
| Aliases | AT rich interactive domain 3A (BRIGHT-like) |
| Synonyms | AT-rich interaction domain 3A, BRIGHT, DRI1, DRIL1, DRIL3, DRX, E2FBP1, LOC687078, LOC690999 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arid3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- activation domain
- transcription regulator
- self-association domain
- tetramerization domain
- transcription cofactor
- chromatin binding
- protein binding
- identical protein binding
- ARID/BRIGHT DNA binding domain
- REKLES domain
- DNA binding
- REKLES beta domain
- ARID/BRIGHT DNA binding domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- atopic dermatitis
- systemic lupus erythematosus
- organismal death
- liver cancer
- rheumatoid arthritis
- COVID-19
- tumorigenesis
- hypoplasia
- juvenile dermatomyositis
role in cell
- expression in
- invasion by
- migration
- number
- growth
- proliferation
- differentiation
- senescence
- immortalization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
- membrane rafts
- PML nuclear bodies
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arid3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane raft
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- transcription cofactor activity
- protein binding
- chromatin binding