Znhit1 Gene Summary [Mouse]
Enables chromatin binding activity and histone deacetylase binding activity. Involved in several processes, including hematopoietic stem cell homeostasis; intestinal stem cell homeostasis; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of T cell proliferation. Located in nucleus. Is expressed in early conceptus; heart; and lens. Orthologous to human ZNHIT1 (zinc finger HIT-type containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Znhit1 |
| Official Name | zinc finger, HIT domain containing 1 [Source:MGI Symbol;Acc:MGI:1917353] |
| Ensembl ID | ENSMUSG00000059518 |
| Bio databases IDs | |
| Aliases | zinc finger, HIT domain containing 1 |
| Synonyms | 2700001K05Rik, CG1I, p18(Hamlet), zinc finger, HIT domain containing 1, zinc finger HIT-type containing 1, zinc finger, HIT-type containing 1, ZNFN4A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Znhit1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- zinc finger HIT (zf-HIT) domain
- histone deacetylase binding
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Znhit1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- calcium ion homeostasis
- positive regulation of transcription initiation from RNA polymerase II promoter
- muscle cell differentiation
- regulation of transcription, DNA-dependent
- heart process
Cellular Component
Where in the cell the gene product is active
- nucleus
- Swr1 complex
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone binding
- nucleosome binding