Actr6 Gene Summary [Mouse]
Predicted to enable nucleosome binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase I; nucleolus organization; and positive regulation of transcription by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be part of Swr1 complex. Is expressed in ovary. Orthologous to human ACTR6 (actin related protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actr6 |
| Official Name | ARP6 actin-related protein 6 [Source:MGI Symbol;Acc:MGI:1914269] |
| Ensembl ID | ENSMUSG00000019948 |
| Bio databases IDs | |
| Aliases | ARP6 actin-related protein 6 |
| Synonyms | 2010200J04Rik, actin related protein 6, Actr6 predicted, ARP6, ARP6 actin-related protein 6, ArpX, CDA12, hARP6, hARPX, HSPC281, MSTP136 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Actr6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Actr6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- nucleolus organization
- regulation of transcription, DNA-dependent
- negative regulation of transcription from RNA polymerase I promoter
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- Swr1 complex
- nucleolus
- nucleosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- nucleosome binding