ZNHIT1 Gene Summary [Human]
Predicted to enable histone deacetylase binding activity and nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to act upstream of or within several processes, including negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of histone deacetylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNHIT1 |
| Official Name | zinc finger HIT-type containing 1 [Source:HGNC Symbol;Acc:HGNC:21688] |
| Ensembl ID | ENSG00000106400 |
| Bio databases IDs | |
| Aliases | zinc finger HIT-type containing 1, putative cyclin G1 interacting protein |
| Synonyms | 2700001K05Rik, CG1I, p18(Hamlet), zinc finger, HIT domain containing 1, zinc finger HIT-type containing 1, zinc finger, HIT-type containing 1, ZNFN4A1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNHIT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- zinc finger HIT (zf-HIT) domain
- histone deacetylase binding
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNHIT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- calcium ion homeostasis
- positive regulation of transcription initiation from RNA polymerase II promoter
- muscle cell differentiation
- regulation of transcription, DNA-dependent
- heart process
Cellular Component
Where in the cell the gene product is active
- nucleus
- Swr1 complex
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone binding
- nucleosome binding