Serpinb12 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Is active in cornified envelope. Is expressed in alimentary system; reproductive system; skin; and thymus. Orthologous to human SERPINB12 (serpin family B member 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinb12 |
| Official Name | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12 [Source:MGI Symbol;Acc:MGI:1919119] |
| Ensembl ID | ENSMUSG00000059956 |
| Bio databases IDs | |
| Aliases | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12 |
| Synonyms | 2300003F07RIK, 4833409F13Rik, LOC103690041, RGD1566382, serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12, serpin family B member 12, YUKOPIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serpinb12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- Plasma Membrane
- secretory granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Serpinb12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein catabolic process
- negative regulation of endopeptidase activity
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular space
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- enzyme binding