Plg Gene Summary [Mouse]
Enables kinase binding activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including embryonic placenta development; muscle cell cellular homeostasis; and myoblast differentiation. Located in cell surface. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in early conceptus; embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in COVID-19; conjunctivitis; hereditary angioedema; plasminogen deficiency type I; and thrombophilia. Orthologous to human PLG (plasminogen). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plg |
| Official Name | plasminogen [Source:MGI Symbol;Acc:MGI:97620] |
| Ensembl ID | ENSMUSG00000059481 |
| Bio databases IDs | |
| Aliases | plasminogen |
| Synonyms | Ab1-346, GLU-PG, HAE4, LPA, Pg, PG2, plasminogen, Scdp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAN_APPLE
- KR
- Trypsin-like serine protease
- lysine binding domain
- peptidase
- serine protease domain
- trypsin
- PAN domain
- chaperone binding
- loop domain
- Tryp_SPc
- protease binding
- catalytic domain
- antigen binding
- Domain of unknown function (DUF1986)
- enzyme binding
- protein domain specific binding
- protein binding
- receptor binding
- plasmin
- protease domain
- endopeptidase
- kinase binding
- serine endopeptidase
- serine-type peptidase
- active site
- Trypsin-like peptidase domain
Pathways
Biological processes and signaling networks where the Plg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- neoplasia
- cancer
- neurodegeneration
- weight loss
- demyelination
- Alzheimer disease
- COVID-19
- infection
- acute ischemic stroke
role in cell
- growth
- expression in
- proliferation
- morphology
- activation in
- phosphorylation in
- activation
- survival
- signaling in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- synaptic cleft
- cell surface
- Nucleus
- Plasma Membrane
- plasma membrane extracellular face
- alpha granules
- synapse
- specific granules
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell homeostasis
- negative regulation of fibrinolysis
- positive regulation of fibrinolysis
- extracellular matrix disassembly
- negative regulation of cell proliferation
- myoblast differentiation
- blood coagulation
- fibrinolysis
- tissue regeneration
- positive regulation of blood vessel endothelial cell migration
- tissue remodeling
- labyrinthine layer blood vessel development
- mononuclear cell migration
- negative regulation of cell-substrate adhesion
- trophoblast giant cell differentiation
- proteolysis
- interaction with symbiont
- negative regulation of cell-cell adhesion mediated by cadherin
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- external side of plasma membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- apolipoprotein binding
- protein domain specific binding
- protein binding
- chaperone binding
- serine-type peptidase activity
- endopeptidase activity
- serine-type endopeptidase activity
- protease binding
- receptor binding
- kinase binding
- enzyme binding