Atxn7l3 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of DUBm complex and SAGA complex. Orthologous to human ATXN7L3 (ataxin 7 like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Atxn7l3 |
| Official Name | ataxin 7-like 3 [Source:MGI Symbol;Acc:MGI:3036270] |
| Ensembl ID | ENSMUSG00000059995 |
| Bio databases IDs | |
| Aliases | ataxin 7-like 3 |
| Synonyms | ataxin 7-like 3, E030022H21Rik, Locuslink 217218, RGD1311493, SGF11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atxn7l3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- Sgf11 (transcriptional regulation protein)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atxn7l3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- regulation of DNA repair
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFTC complex
- DUBm complex
- SAGA complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity