Ipmk Gene Summary [Mouse]
Enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within inositol phosphate biosynthetic process and neural tube formation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; hindlimb ridge; nervous system; retina nuclear layer; and trunk somite. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ipmk |
| Official Name | inositol polyphosphate multikinase [Source:MGI Symbol;Acc:MGI:1916968] |
| Ensembl ID | ENSMUSG00000060733 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate multikinase |
| Synonyms | 2410017C19Rik, Impk, INOSITOL 1,3,4,6-TETRAKISPHOSPHATE 5-KINASE, inositol polyphosphate multikinase, Insp4 5-Kinase, Ipk2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ipmk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-polyphosphate multikinase
- binding protein
- inositol-trisphosphate 3-kinase
- inositol-hexakisphosphate kinase
- alcohol group acceptor phosphotransferase
- Inositol polyphosphate kinase
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- inositol-tetrakisphosphate 5-kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- Crohn disease
- growth failure
- chorioallantoic membrane fusion failure
- Huntington disease
- ulcerative colitis
- idiopathic scoliosis
- dextran sodium sulfate-induced colitis
role in cell
- differentiation
- expression in
- production in
- cell death
- quantity
- proliferation
- migration
- binding in
- adhesion
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- basal bodies
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ipmk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol trisphosphate metabolic process
- inositol phosphate metabolic process
- inositol phosphate biosynthetic process
- necroptosis
- phosphatidylinositol metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- flavonoid binding
- ATP binding
- protein binding
- inositol-1,4,5-trisphosphate 3-kinase activity
- metal ion binding
- inositol tetrakisphosphate 6-kinase activity
- inositol tetrakisphosphate 3-kinase activity
- inositol-1,4,5-trisphosphate 6-kinase activity
- inositol tetrakisphosphate 5-kinase activity
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- inositol tetrakisphosphate kinase activity