Csnk2a2 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Acts upstream of or within protein phosphorylation; regulation of cell cycle; and spermatogenesis. Predicted to be located in acrosomal vesicle and chromatin. Predicted to be part of PcG protein complex and protein kinase CK2 complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study male infertility. Orthologous to human CSNK2A2 (casein kinase 2 alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csnk2a2 |
| Official Name | casein kinase 2, alpha prime polypeptide [Source:MGI Symbol;Acc:MGI:88547] |
| Ensembl ID | ENSMUSG00000046707 |
| Bio databases IDs | |
| Aliases | casein kinase 2, alpha prime polypeptide |
| Synonyms | 1110035J23RIK, C77789, CASEIN KINASE 2, casein kinase 2 alpha 2, casein kinase 2, alpha prime polypeptide, casein kinase 2 α 2, casein kinase 2, α prime polypeptide, Casein kinase II, alpha 2, polypeptide, Casein kinase II, α 2, polypeptide, CK2, CK2A', CK2A2, CK2 alpha', CK2alpha2, Ck2 alpha prime, CK2 α', CK2α2, Ck2 α prime, CSNK2A1, Csnk2a2 predicted |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csnk2a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- protein binding
- Protein kinase domain
Pathways
Biological processes and signaling networks where the Csnk2a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- oligozoospermia
- glioma
- glioma formation
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- globozoospermia
- dysplasia
- teratozoospermia
- osteosarcoma
role in cell
- expression in
- apoptosis
- accumulation in
- activation in
- proliferation
- phosphorylation in
- number
- abnormal morphology
- neuritogenesis
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- acrosome
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csnk2a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- apoptotic process
- Wnt receptor signaling pathway
- cerebral cortex development
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- negative regulation of apoptotic signaling pathway
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- protein kinase CK2 complex
- acrosomal vesicle
- PcG protein complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity