Serpina6 Gene Summary [Mouse]
This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Serpina6 |
| Official Name | serine (or cysteine) peptidase inhibitor, clade A, member 6 [Source:MGI Symbol;Acc:MGI:88278] |
| Ensembl ID | ENSMUSG00000060807 |
| Bio databases IDs | |
| Aliases | serine (or cysteine) peptidase inhibitor, clade A, member 6 |
| Synonyms | CBG, Corticosteroid-binding globulin, serine (or cysteine) peptidase inhibitor, clade A, member 6, serpin family A member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serpina6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- Serpin (serine protease inhibitor)
- steroid binding
Pathways
Biological processes and signaling networks where the Serpina6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fatigue
- osteoporosis
- corticosteroid-binding globulin deficiency
- early onset hypertension
- cholangiocarcinoma
- cholangiocarcinoma cancer
- functional hypothalamic amenorrhea
- femoral fracture
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Serpina6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endopeptidase activity
- glucocorticoid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- steroid binding