Serpinf1 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of angiogenesis. Acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study osteogenesis imperfecta type 6. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinf1 |
| Official Name | serine (or cysteine) peptidase inhibitor, clade F, member 1 [Source:MGI Symbol;Acc:MGI:108080] |
| Ensembl ID | ENSMUSG00000000753 |
| Bio databases IDs | |
| Aliases | serine (or cysteine) peptidase inhibitor, clade F, member 1 |
| Synonyms | DMRS91, EPC-1, OI12, OI6, PEDF, PEDFL, PIG35, pigment epithelium-derived factor, Sdf3, serine (or cysteine) peptidase inhibitor, clade F, member 1, serpin family F member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serpinf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- laminin receptor binding domain
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Serpinf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- Alzheimer disease
- cancer
- COVID-19
- metastasis
- osteogenesis imperfecta type VI
- osteogenesis imperfecta
- dengue shock syndrome
- keratocystic odontogenic tumor
role in cell
- damage
- apoptosis
- survival
- activation in
- cell death
- binding
- phosphorylation in
- expression in
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- cell periphery
- perinuclear region
- Plasma Membrane
- axon hillock
- perikaryon
- axons
- exosomes
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Serpinf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial cell proliferation involved in prostate gland development
- negative regulation of angiogenesis
- retina development in camera-type eye
- epithelial cell proliferation involved in prostate gland development
- ovulation cycle
- negative regulation of gene expression
- short-term memory
- kidney development
- response to arsenic-containing substance
- cellular response to retinoic acid
- cellular response to glucose stimulus
- negative regulation of endopeptidase activity
- positive regulation of neuron projection development
- cellular response to cobalt ion
- response to acidity
- positive regulation of neurogenesis
- cellular response to dexamethasone stimulus
- negative regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- melanosome
- extracellular region
- axon hillock
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding