Coch Gene Summary [Mouse]
Predicted to enable collagen binding activity. Acts upstream of or within sensory perception of sound. Located in extracellular matrix. Is expressed in central nervous system; inner ear; olfactory epithelium; and vibrissa. Used to study autosomal dominant nonsyndromic deafness 9. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 9 and autosomal recessive nonsyndromic deafness 110. Orthologous to human COCH (cochlin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coch |
| Official Name | cochlin [Source:MGI Symbol;Acc:MGI:1278313] |
| Ensembl ID | ENSMUSG00000020953 |
| Bio databases IDs | |
| Aliases | cochlin |
| Synonyms | COCH-5B2, COCHLIN, D12H14S564E, DFNA9, DFNB110, Lulu |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coch often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor (vWF) type A domain
- vWFA
- collagen binding
- LCCL domain
- protein binding
- von Willebrand factor type A domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Alzheimer disease
- hepatocellular carcinoma
- Huntington disease
- breast cancer
- small cell lung cancer
- plasma cell myeloma
- familial nonsyndromic hearing impairment
- glaucoma
- lung squamous cell carcinoma
role in cell
- recruitment
- expression in
- differentiation
- cytotoxic reaction
- clearance
- colonization by
- cell survival
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum/Golgi apparatus fractions
- Cytoplasm
- cellular membrane
- Nucleus
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coch gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- sensory perception of sound
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding