Maml3 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription of Notch receptor target. Predicted to be located in nuclear speck. Predicted to be active in nucleoplasm. Is expressed in several structures, including forelimb bud; genitourinary system; neural ectoderm; pancreas epithelium; and paraxial mesenchyme. Orthologous to human MAML3 (mastermind like transcriptional coactivator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maml3 |
| Official Name | mastermind like transcriptional coactivator 3 [Source:MGI Symbol;Acc:MGI:2389461] |
| Ensembl ID | ENSMUSG00000061143 |
| Bio databases IDs | |
| Aliases | mastermind like transcriptional coactivator 3 |
| Synonyms | AV234550, CAGH3, ERDA3, GDN, Glrp1, MAM-2, mam-3, mastermind-like transcriptional coactivator 3, mKIAA1816, TNRC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Maml3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MamL-1 domain
- transcription regulator
- transcription co-activator
- protein binding
- basic domain
Pathways
Biological processes and signaling networks where the Maml3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- congenital heart disease
- schizophrenia
- androgenic alopecia
- major depression
- malaria
- gastroesophageal reflux
- idiopathic scoliosis
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Maml3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- positive regulation of transcription of Notch receptor target
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity