Dpp6 Gene Summary [Mouse]
Enables potassium channel regulator activity. Involved in protein localization to plasma membrane; regulation of postsynaptic membrane potential; and regulation of potassium ion transmembrane transport. Acts upstream of or within neuronal action potential and positive regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is active in synapse. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; intervertebral disc; and nose. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dpp6 |
| Official Name | dipeptidylpeptidase 6 [Source:MGI Symbol;Acc:MGI:94921] |
| Ensembl ID | ENSMUSG00000061576 |
| Bio databases IDs | |
| Aliases | dipeptidylpeptidase 6 |
| Synonyms | B930011P16Rik, D5Buc3, D5Buc4, D5Buc5, DIPEPTIDYL AMINOPEPTIDASE LIKE, dipeptidylpeptidase 6, dipeptidyl peptidase like 6, DPL1, DPP VI, DPPX, Gm1377, In(5)6H-p, MRD33, Peplb, Rw, VF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- Dipeptidyl peptidase IV (DPP IV) N-terminal region
- potassium channel regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- uterine serous papillary cancer
- pancreatic epithelial cancer
- survival
- pancreatic carcinoma
- amyotrophic lateral sclerosis
- essential tremor
- diabetic nephropathy
- alcohol use disorder
- colorectal cancer
regulated by
- ZNF217
- butyric acid
- haloperidol
- Influenza A virus (A/Bangkok/RX73(H3N2))
regulates
- KCND2
- ion channel
- K+
role in cell
- transmembrane potential
- long-term potentiation
- action potential
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- membrane fraction
- cell surface
- cellular membrane
- synaptic vesicles
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type peptidase activity
- potassium channel regulator activity
- dipeptidyl-peptidase activity