Tmem65 Gene Summary [Mouse]
Involved in cardiac conduction; cardiac ventricle development; and regulation of cardiac conduction. Located in intercalated disc and plasma membrane. Is expressed in dentate gyrus subgranular zone. Orthologous to human TMEM65 (transmembrane protein 65). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem65 |
| Official Name | transmembrane protein 65 [Source:MGI Symbol;Acc:MGI:1922118] |
| Ensembl ID | ENSMUSG00000062373 |
| Bio databases IDs | |
| Aliases | transmembrane protein 65 |
| Synonyms | 2610029O13RIK, 4930438D12Rik, LOC286052, RGD1563224, transmembrane protein 65 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem65 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 65
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- Mitochondria
- intercellular junctions
- mitochondrial inner membrane
- nucleoli
- intercalated disks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem65 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cardiac ventricle development
- cardiac conduction
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- intercalated disc
- plasma membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding