Retreg3 Gene Summary [Mouse]
Enables endoplasmic reticulum-autophagosome adaptor activity. Acts upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RETREG3 (reticulophagy regulator family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Retreg3 |
| Official Name | reticulophagy regulator family member 3 [Source:MGI Symbol;Acc:MGI:1915248] |
| Ensembl ID | ENSMUSG00000017802 |
| Bio databases IDs | |
| Aliases | reticulophagy regulator family member 3 |
| Synonyms | 1300010M03Rik, 4933404C01Rik, FAM134C, GT212, reticulophagy regulator family member 3, RGD1561189 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Retreg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reticulon
- protein binding activity, bridging
- protein binding
- Arl6IP1_RETR3-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- endometrium tumor
regulated by
- beta-estradiol
- phenobarbital
- decitabine
- tazemetostat
- SP2509
- trichostatin A
- PTEN
- diethylnitrosamine
role in cell
- loss
- formation
- formation in
- development
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum tubules
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Retreg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- collagen catabolic process
- positive regulation of neuron projection development
- endoplasmic reticulum tubular network organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum tubular network
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding