Sra1 Gene Summary [Mouse]
Predicted to enable nuclear receptor binding activity; steroid receptor RNA activator RNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; negative regulation of myoblast differentiation; and regulation of mitotic cell cycle. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nucleoplasm. Predicted to be part of SCAR complex and ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human SRA1 (steroid receptor RNA activator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sra1 |
| Official Name | steroid receptor RNA activator 1 [Source:MGI Symbol;Acc:MGI:1344414] |
| Ensembl ID | ENSMUSG00000006050 |
| Bio databases IDs | |
| Aliases | steroid receptor RNA activator 1 |
| Synonyms | MGC87674, PP7684, SRA, SRAP, steroid receptor RNA activator 1, STRAA1, Strra1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sra1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Steroid receptor RNA activator (SRA1)
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- protein binding
- single-stranded RNA binding
Pathways
Biological processes and signaling networks where the Sra1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
role in cell
- activation in
- expression in
- differentiation
- quantity
- invasion
- engulfment by
- uptake by
- engulfment
- uptake
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- Plasma Membrane
- cytoplasmic bridges
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sra1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of myoblast differentiation
- positive regulation of transcription, DNA-dependent
- apoptotic process
- cell differentiation
- regulation of apoptotic process
- cellular response to estrogen stimulus
- regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- SCAR complex
- microtubule cytoskeleton
- intercellular bridge
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- steroid receptor RNA activator RNA binding