Dgkk Gene Summary [Mouse]
Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process; intracellular signal transduction; and response to oxidative stress. Predicted to be active in plasma membrane. Is expressed in central nervous system; external genitalia; genital tubercle epithelium; lung; and urethra. Orthologous to human DGKK (diacylglycerol kinase kappa). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgkk |
| Official Name | diacylglycerol kinase kappa [Source:MGI Symbol;Acc:MGI:3580254] |
| Ensembl ID | ENSMUSG00000062393 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase kappa |
| Synonyms | DGK KAPPA, DGK κ, diacylglycerol kinase kappa, diacylglycerol kinase κ, Gm360, RGD1561510 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgkk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cornifin (SPRR) family
- diacylglycerol kinase
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- PH domain
- Diacylglycerol kinase catalytic domain
- Pleckstrin homology-like domain
- YegS C-terminal NAD kinase beta sandwich-like domain
- Diacylglycerol kinase catalytic domain (presumed)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- hypospadia
- behavioral deficit
regulates
- diacylglycerol
- phosphatidic acid
role in cell
- plasticity
- activation
- morphology
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgkk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- diacylglycerol kinase activity