Ldb1 Gene Summary [Mouse]
Enables several functions, including LIM domain binding activity; protein homodimerization activity; and transcription coactivator activity. Contributes to DNA binding activity. Involved in several processes, including negative regulation of erythrocyte differentiation; positive regulation of macromolecule biosynthetic process; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; epithelial structure maintenance; and hair follicle development. Located in cell leading edge and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; eye; and genitourinary system. Used to study nail-patella syndrome. Orthologous to human LDB1 (LIM domain binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldb1 |
| Official Name | LIM domain binding 1 [Source:MGI Symbol;Acc:MGI:894762] |
| Ensembl ID | ENSMUSG00000025223 |
| Bio databases IDs | |
| Aliases | LIM domain binding 1 |
| Synonyms | CLIM-2, LIM domain binding 1, NLI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ldb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM-domain binding
- transcription regulator
- dimerization domain
- transcription co-activator
- transcription cofactor
- enzyme binding
- transcription factor binding
- chromatin binding
- protein binding
- lid domain
- identical protein binding
- DNA binding
- LIM interaction domain (LID)
- LIM binding domain
- protein homodimerization
- LIM-domain binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperglycemia
- impaired glucose tolerance
- medulloblastoma SHH subtype
- brain cancer
- hypoinsulinemia
- medulloblastoma
- pervasive developmental disorder
- T acute lymphoblastic leukemia
- squamous cell cancer of the oral cavity
role in cell
- maturation
- expression in
- proliferation
- apoptosis
- number
- colony formation by
- growth
- migration
- abnormal morphology
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- cell membrane leading edge
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ldb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinase activity
- cerebellar Purkinje cell differentiation
- neuron differentiation
- cellular component assembly
- nervous system development
- positive regulation of hemoglobin biosynthetic process
- transcription from RNA polymerase II promoter
- cell adhesion
- positive regulation of cell adhesion
- negative regulation of erythrocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation from RNA polymerase II promoter
- anterior/posterior axis specification
- regulation of focal adhesion assembly
- hair follicle development
- negative regulation of transcription, DNA-dependent
- epithelial structure maintenance
- gastrulation with mouth forming second
- somatic stem cell maintenance
- Wnt receptor signaling pathway
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cell leading edge
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein homodimerization activity
- protein binding
- transcription coactivator activity
- LIM domain binding
- chromatin binding
- enzyme binding