DGKK Gene Summary [Human]
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | DGKK |
| Official Name | diacylglycerol kinase kappa [Source:HGNC Symbol;Acc:HGNC:32395] |
| Ensembl ID | ENSG00000274588 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase kappa |
| Synonyms | DGK KAPPA, DGK κ, diacylglycerol kinase kappa, diacylglycerol kinase κ, Gm360, RGD1561510 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DGKK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cornifin (SPRR) family
- diacylglycerol kinase
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- PH domain
- Diacylglycerol kinase catalytic domain
- Pleckstrin homology-like domain
- YegS C-terminal NAD kinase beta sandwich-like domain
- Diacylglycerol kinase catalytic domain (presumed)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- hypospadia
- behavioral deficit
regulates
- diacylglycerol
- phosphatidic acid
role in cell
- plasticity
- activation
- morphology
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DGKK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- diacylglycerol kinase activity